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KMID : 0361519940050020168
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Korean Journal of Psychopharmacology
1994 Volume.5 No. 2 p.168 ~ p.176
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Effect of ALTO, Herbal Extract on the Blood Ethanol Concentration and Clinical Effects of Ethanol in Human
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김영훈
신재국/김용관/장태섭/김재홍/윤영란/차인준/김문희/박찬구
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Abstract
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We evaluated the effect of ALTO. Herbal extract. On the disposition of blood ethanol and acute alcoholic intoxiciation and hangover. Thirty minutes before the administration of ethanol 59.2g (25% alcohol 300ml). Two single doses of placebo or
ALTO
150ml
were pretreated orally to 12 normal volunteers in a balanced. Randomized crossover design.
Pretreatemtn of ALTO significantly lowered the blood ethanol concentration (BEC) with statistical significance compared to those of placebo (p=0.013). AUC0→12hr, Cmax, and T30 of BEC showed statistically significant difference between two
preteatments
by ANOVA (p<0.05) and were reduced 24.12±25.20% 15.46±23.93%, and 16.73±23.50% in the case of ALTO pretreatment, respectively. All parameters interal. No statistically significant difference was identified between two pretreatments when we
assessed
the psychomotor performance, subjective and objective signs of hangover.
These results suggested that herbal extract ALTO decreased the blood ethanol concentration, though the effect of ALTC showed significant interindividual variation.
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